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KMID : 0882420120830050683
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Korean Journal of Medicine
2012 Volume.83 No. 5 p.683 ~ p.687
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A Case of Miller Fisher Syndrome in a Patient with Systemic Lupus Erythematosus
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Lee Yong-Kang
Park Yoon-Hye
Choi A-Ra
Lee Chan-Hee
Cho Jeong-Hee
Kim Hye-Young
Yoon Pyeong-Ho
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Abstract
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Neuropsychiatric events are common in patients with systemic lupus erythematosus (SLE). The estimated incidence of neuropsychiatric SLE (NPSLE) is 30 to 40%. However, NPSLE poses a difficult diagnostic challenge because a variety of conditions should be considered in the differential diagnosis, especially when patients present with uncommon or rare NPSLE features. We herein describe a 49-year-old man with SLE who initially presented with diplopia, ptosis, and gait disturbance that had developed 1 week after an upper respiratory tract infection. He was finally diagnosed with Miller Fisher syndrome (a variant of Guillain-Barre syndrome) according to clinical symptoms, anti-GQ1b antibody positivity, and neurological study results. The patient recovered without sequelae with intravenous immunoglobulin therapy. This is the first report to describe a case of Miller Fisher syndrome that developed in a patient with SLE in Korea and suggests that Miller Fisher syndrome should be included as a differential diagnosis of NPSLE.
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KEYWORD
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Anti-GQ1b antibody, Miller Fisher syndrome, Systemic lupus erythematosus
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